Point and interval estimation of primary and secondary parameters in a two-stage adaptive clinical trial.
J Biopharm Stat
; 18(2): 211-26, 2008.
Article
em En
| MEDLINE
| ID: mdl-18327717
ABSTRACT
Investigated in this paper is the point estimation and confidence intervals of the treatment efficacy parameter and related secondary parameters in a two-stage adaptive trial. Based on the minimal sufficient statistics, several alternative estimators to the sample averages are proposed to reduce the bias and to improve the precision of estimation. Confidence intervals are constructed using Woodroofe's pivot method. Numerical studies are conducted to evaluate the bias and mean squared error of the estimators and the coverage probability of the confidence intervals.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Intervalos de Confiança
/
Ensaios Clínicos como Assunto
/
Modelos Estatísticos
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
J Biopharm Stat
Assunto da revista:
FARMACOLOGIA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos