Anaphylactoid reaction to high-dose methotrexate and re-administration after a successful desensitization.
Pediatr Hematol Oncol
; 25(2): 131-4, 2008 Mar.
Article
em En
| MEDLINE
| ID: mdl-18363180
ABSTRACT
Methotrexate (MTX) is an antimetabolite with a major role in the treatment of acute lymphoblastic leukaemia (ALL). The authors report the management of a 9-year-old boy who developed an anaphylactoid reaction to high-dose MTX infusion, after a first challenge with intrathecal administration, during induction therapy for ALL. A desensitization protocol was followed and MTX tolerance has been successfully achieved, allowing this patient to complete the needed chemotherapy.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Leucemia-Linfoma de Células T do Adulto
/
Metotrexato
/
Dessensibilização Imunológica
/
Hipersensibilidade a Drogas
/
Anafilaxia
/
Antimetabólitos Antineoplásicos
Tipo de estudo:
Guideline
Limite:
Child
/
Humans
/
Male
Idioma:
En
Revista:
Pediatr Hematol Oncol
Assunto da revista:
HEMATOLOGIA
/
NEOPLASIAS
/
PEDIATRIA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Portugal