Ixabepilone, a novel epothilone analog in the treatment of breast cancer.
Expert Opin Investig Drugs
; 17(4): 593-9, 2008 Apr.
Article
em En
| MEDLINE
| ID: mdl-18363523
ABSTRACT
BACKGROUND:
Natural epothilones and their analogs promote tumor cell death by binding to tubulin and stabilizing microtubules, causing cell death. Ixabepilone (BMS-247550, Ixempra) is an epothilone analog that optimizes the properties naturally observed with epothilone B.OBJECTIVE:
To provide an overview of the results achieved by ixabepilone in metastatic breast cancer.METHODS:
A PubMed search was performed to provide an extensive review of all published data on ixabepilone, in addition to all data reported from international congresses, from 2003 to 2007. RESULTS/CONCLUSION:
There is a clear need for new agents active against resistant metastatic breast cancer and ixabepilone might be a welcome new compound in this situation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Epotilonas
/
Moduladores de Tubulina
/
Antineoplásicos
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Expert Opin Investig Drugs
Assunto da revista:
TERAPIA POR MEDICAMENTOS
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
França