Deviations of drug solubility in water-cosolvent mixtures from the Jouyban-Acree model--effect of solute structure.
Pharmazie
; 63(2): 113-21, 2008 Feb.
Article
em En
| MEDLINE
| ID: mdl-18380397
ABSTRACT
Deviations of the predicted solubilities using the Jouyban-Acree model from experimental data were correlated to the structural descritptors of the drugs computed by HyperChem software. The proposed models are able to predict the solubility in water-cosolvent mixtures and reduced the mean percentage deviations (MPD) of predicted solubilities from 24%, 48%, and 53% to 16%, 33% and 38%, respectively for water-propylene glycol, water-ethanol and water-polyethylene glycol 400 mixtures, with the overall improvement in prediction capability of the model being approximately 13%.
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Base de dados:
MEDLINE
Assunto principal:
Preparações Farmacêuticas
/
Química Farmacêutica
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Pharmazie
Assunto da revista:
FARMACIA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Irã