[Cellular energetic metabolism of cerebral tissue: metabolic characteristics of glial tumours]. / Métabolisme énergétique cellulaire du tissu cérébral: spécificités métaboliques des tumeurs gliales.
Ann Biol Clin (Paris)
; 66(2): 131-41, 2008.
Article
em Fr
| MEDLINE
| ID: mdl-18390423
ABSTRACT
This review reports recent observations concerning specificities of the cellular energy metabolism in cerebral tissues that highlight on characteristics of that of glial tumours, such as the association of metabolic alterations aggressiveness of these tumours. Compared to normal cerebral tissue, glial tissue exhibits both a relative independence towards oxygen and substrate furnitures and thus vascularization, as well as the metabolic co-operation of neurons and glial cells within the tumour. Occurrence of a Warburg effect could explain such metabolic autonomy that might be associated to genetic changes observed in gliomas. Characteristics of the glycolytic metabolism within glioma tissue therefore may be novel land therapeutic approaches for the treatment of these tumours.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Neoplasias Encefálicas
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Metabolismo Energético
/
Glioma
Tipo de estudo:
Prognostic_studies
Limite:
Adult
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Animals
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Child
/
Humans
Idioma:
Fr
Revista:
Ann Biol Clin (Paris)
Ano de publicação:
2008
Tipo de documento:
Article