Cognitive impairment and epilepsy seizure caused by hypoparathyroidism.

ABSTRACT

We report a 46-years-old man with idiopathic hypoparathyroidism who presented with gradually cognitive impairment and generalized tonic clonic epilepsy. Computed tomography (CT) and magnetic resonance imaging (MRI) of brain showed calcification in the basal ganglia, thalamus and cerebral white matter. Calcium level was low and phosphor was increased in serum, but parathormon level was low. Following introduction of replacement therapy, cognitive functions improved as well. After treatment with calcium and vitamin D supplementation he showed clinical, cognitive impariment and laboratory improvements (Fig. 2, Ref. 13).