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Effect of antipsychotics on peptides involved in energy balance in drug-naive psychotic patients after 1 year of treatment.
Perez-Iglesias, Rocio; Vazquez-Barquero, Jose Luis; Amado, Jose Antonio; Berja, Ana; Garcia-Unzueta, Maria Teresa; Pelayo-Terán, Jose María; Carrasco-Marín, Eugenio; Mata, Ignacio; Crespo-Facorro, Benedicto.
Afiliação
  • Perez-Iglesias R; Department of Psychiatry, Marqués de Valdecilla University Hospital, University of Cantabria, Cantabria, Spain.
J Clin Psychopharmacol ; 28(3): 289-95, 2008 Jun.
Article em En | MEDLINE | ID: mdl-18480685
ABSTRACT
Weight gain has become one of the most common and concerning side effects of antipsychotic treatment. The mechanisms whereby antipsychotics induce weight gain are not known. It has been suggested that peptides related to food intake and energy balance could play a role in weight gain secondary to antipsychotic therapy. To better understand the pathophysiology of antipsychotic-induced weight gain, we studied the effects of 3 antipsychotic drugs (haloperidol, olanzapine, and risperidone) on peptides involved in energy balance (insulin, ghrelin, leptin, adiponectin, visfatin, and resistin) in a population of drug-naive patients with first episode of psychosis.A significant increase in weight (10.16 kg [SD, 8.30 kg]; P < 0.001), body mass index (3.56 kg/m [SD, 2.89 kg/m]; P < 0.001), and fasting insulin (3.93 muU/mL [SD, 3.93 muU/mL]; P = 0.028), leptin (6.76 ng/mL [SD, 7.21 ng/mL]; P < 0.001), and ghrelin (15.47 fmol/mL [SD, 47.90 fmol/mL]; P = 0.009) plasma levels were observed. The increments in insulin and leptin concentrations were highly correlated with the increment in weight and body mass index and seem to be a consequence of the higher fat stores. The unexpected increase in ghrelin levels might be related with the causal mechanism of weight gain induced by antipsychotics. Finally, the 3 antipsychotics had similar effects in all parameters evaluated.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtornos Psicóticos / Esquizofrenia / Antipsicóticos / Aumento de Peso / Leptina / Metabolismo Energético / Grelina / Insulina Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Clin Psychopharmacol Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Espanha

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtornos Psicóticos / Esquizofrenia / Antipsicóticos / Aumento de Peso / Leptina / Metabolismo Energético / Grelina / Insulina Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Clin Psychopharmacol Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Espanha