[The interaction between anticoagulant therapy with vitamin K-antagonists and treatment with antibiotics: a practical recommendation]. / De interactie tussen antistollingstherapie met vitamine K-antagonisten en behandeling met antibiotica: een praktische aanbeveling.
Ned Tijdschr Geneeskd
; 152(18): 1042-6, 2008 May 03.
Article
em Nl
| MEDLINE
| ID: mdl-18547025
ABSTRACT
--In users of vitamin K-antagonists (VKA), antibiotics can lead to excessive anticoagulation. --It is unclear what the optimal policy is for prevention of an excessive anticoagulant effect during use of antibiotics. --This article describes the increased sensitivity to VKA during use of antibiotics, and also provides a practical recommendation for the correct method for use of antibiotics in combination with VKA treatment. --During use of antibiotics for more than one day, the prothrombin time-'international normalized ratio' (PTT-INR) must be checked both after 3 and after 7 days, and the dose of VKA must be adapted if necessary. --Use of co-trimoxazole for more than one day should, if possible, be avoided.
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Base de dados:
MEDLINE
Assunto principal:
Vitamina K
/
Antibacterianos
/
Anticoagulantes
Tipo de estudo:
Etiology_studies
/
Guideline
/
Risk_factors_studies
Limite:
Humans
Idioma:
Nl
Revista:
Ned Tijdschr Geneeskd
Ano de publicação:
2008
Tipo de documento:
Article