Murine norovirus, a recently discovered and highly prevalent viral agent of mice.
Lab Anim (NY)
; 37(7): 314-20, 2008 Jul.
Article
em En
| MEDLINE
| ID: mdl-18568010
ABSTRACT
Murine norovirus (MNV), a recently discovered viral agent of laboratory mice, is closely related to human norovirus, a contagious pathogen known to cause gastroenteritis. The prototype strain of MNV (MNV-1) was first isolated and characterized in 2003 as a sporadic, lethal pathogen in certain strains of immunocompromised knockout mice. Serological surveillance data from mouse colonies throughout the US and Canada have since shown that MNV is highly prevalent. Because MNV is unique among norovirus strains in its ability to replicate in cell culture, it serves as the most accessible model to elucidate the mechanisms of infection and replication of human norovirus. The author discusses the genetic diversity of MNV, its prevalence, pathology and potential research implications, as well as techniques for detection and eradication of this virus.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças dos Roedores
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Infecções por Caliciviridae
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Norovirus
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Gastroenterite
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Camundongos
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Lab Anim (NY)
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos