Remission in the outpatient care of schizophrenia: 3-year results from the Schizophrenia Outpatients Health Outcomes (SOHO) study in France.
Eur Psychiatry
; 23(7): 491-6, 2008 Oct.
Article
em En
| MEDLINE
| ID: mdl-18573640
ABSTRACT
OBJECTIVE:
To analyse the contribution of socio-demographics, clinical profile and psychotropic treatment on remission in patients with schizophrenia.METHODS:
Among 933 French outpatients recruited in the European observational Schizophrenia Outpatient Health Outcomes study (SOHO), 563 were followed-up for 3 years, had at most one missing visit, and were included in the analysis. Symptomatic remission was defined as a score of 3 (mild severity) or less on the Clinical Global Impression-Schizophrenia (CGI) overall, positive, negative and cognitive symptom scales, maintained for at least 6 months and without hospitalization. A logistic regression model was used to analyse the factors associated with time in remission.RESULTS:
60.6% of patients achieved remission during the 3-year follow-up. Patients never treated before inclusion in the study (OR=2.3) and those having paid employment (OR=1.4) were more likely to achieve remission. Higher baseline clinical severity was associated with a significantly lower likelihood of achieving remission CGI overall (OR=0.67), CGI positive (OR=0.85) and CGI negative (OR=0.74). Compared with olanzapine, other atypicals (OR=0.71) and conventional antipsychotics (OR=0.69) were associated with a lower probability of achieving remission.CONCLUSIONS:
Remission can be achieved in a high proportion of patients. Factors such as being previously untreated, having paid employment and taking olanzapine are predictors of remission.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Avaliação de Resultados em Cuidados de Saúde
/
Assistência Ambulatorial
Tipo de estudo:
Etiology_studies
/
Incidence_studies
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Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
Eur Psychiatry
Assunto da revista:
PSIQUIATRIA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
França