Parallel synthesis and antileishmanial activity of ether-linked phospholipids.
Bioorg Med Chem Lett
; 18(16): 4658-60, 2008 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-18644723
ABSTRACT
The synthesis and antileishmanial activity of 18 edelfosine analogues are described. Compounds were obtained in parallel combining solid phase and solution phase synthesis. The most active analogue is characterized by the octadecyl group in position 2 of the glycerol chain. Considering that this substitution determines the loss of antitumor activity, a different mechanism of antileishmanial action can be hypothesized.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fosfolipídeos
/
Química Farmacêutica
/
Antiprotozoários
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Itália