Association of the polymorphisms of MTHFR C677T, VDR C352T, and MPO G463A with risk for esophageal squamous cell dysplasia and carcinoma.
Arch Med Res
; 39(6): 594-600, 2008 Aug.
Article
em En
| MEDLINE
| ID: mdl-18662591
ABSTRACT
BACKGROUND:
From January 2004 to December 2006 a program of endoscopic screening for esophageal lesions was carried out in the high incidence area of esophageal cancer in Feicheng County, China. It provided the samples to evaluate the association of polymorphisms of methylenetetrahydrofolate reductase (MTHFR) C677T, vitamin D receptor (VDR) C352T, and myeloperoxidase (MPO) G463A genotypes with esophageal squamous cell dysplasia and carcinoma.METHODS:
The subjects in the study were divided into 127 dysplasia cases, 126 squamous cell carcinoma cases, and 169 normal controls. Analyses of the MTHFR C677T, VDR C352T, and MPO G463A genotypes were performed using the PCR-restriction fragment length polymorphism (RFLP) method, whereas the multinomial logistic regression model was used in the data analysis to assess the odds ratios (ORs) related to dysplasia and carcinoma.RESULTS:
Compared with the CC genotype of MTHFR C677T, the TT/TC of the genotype significantly increased the risk of the esophageal squamous cells dysplasia [OR, 2.25; 95% confidence interval (CI), 1.18-4.31]; the OR of esophageal squamous cancer was 1.58 (95% CI, 0.85-2.97) after adjustments for age, sex, and years of education. There was an interaction between the TT/TC genotype and alcohol drinking, smoking, and family history of esophageal cancer in the risk of esophageal dysplasia and carcinoma.CONCLUSIONS:
Neither the VDR C352T nor the MPO G463A genotype had manifested association with the dysplasia and carcinoma of the disease, whereas the MTHFR 677TT genotype may be a genetic risk factor for esophageal dysplasia and carcinoma.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Lesões Pré-Cancerosas
/
Neoplasias Esofágicas
/
Carcinoma de Células Escamosas
/
Receptores de Calcitriol
/
Peroxidase
/
Metilenotetra-Hidrofolato Redutase (NADPH2)
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
/
Middle aged
Idioma:
En
Revista:
Arch Med Res
Assunto da revista:
MEDICINA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
China