Pulmonary function, muscle strength and mortality in old age.
Mech Ageing Dev
; 129(11): 625-31, 2008 Nov.
Article
em En
| MEDLINE
| ID: mdl-18755207
ABSTRACT
Numerous reports have linked extremity muscle strength with mortality but the mechanism underlying this association is not known. We used data from 960 older persons without dementia participating in the Rush Memory and Aging Project to test two sequential hypotheses first, that extremity muscle strength is a surrogate for respiratory muscle strength, and second, that the association of respiratory muscle strength with mortality is mediated by pulmonary function. In a series of proportional hazards models, we first demonstrated that the association of extremity muscle strength with mortality was no longer significant after including a term for respiratory muscle strength, controlling for age, sex, education, and body mass index. Next, the association of respiratory muscle strength with mortality was attenuated by more than 50% and no longer significant after including a term for pulmonary function. The findings were unchanged after controlling for cognitive function, parkinsonian signs, physical frailty, balance, physical activity, possible COPD, use of pulmonary medications, vascular risk factors including smoking, chronic vascular diseases, musculoskeletal joint pain, and history of falls. Overall, these findings suggest that pulmonary function may partially account for the association of muscle strength and mortality.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Músculo Esquelético
/
Debilidade Muscular
/
Força Muscular
/
Pulmão
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Mech Ageing Dev
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos