Animal models of anxiety: do I need multiple tests?
Trends Pharmacol Sci
; 29(10): 493-8, 2008 Oct.
Article
em En
| MEDLINE
| ID: mdl-18755516
ABSTRACT
The combination of cutting-edge molecular technology and high-throughput phenotyping tools will not bring the expected contribution to the pre-clinical study of anxiety if not paralleled by an increase in our capacity to interpret behavioral data. Here, previous views about the multidimensional nature of emotional behaviors will be expanded and the psychological meaning and behavioral overlaps of widely used anxiety tests such as the open field, elevated plus maze and light-dark box will be discussed. It is proposed here that short-term, intra-individual variations in emotionality, although normally overlooked, constitute an important factor in the study of anxiety and can lead to unreliable estimates of the similarities between tests. The physical integration of different current tests in one single apparatus, in such a way that the emotional status of an animal becomes assessable through a series of distinct tasks, could contribute to increase reliability, rapidity and comprehensiveness in behavioral testing.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transtornos de Ansiedade
/
Comportamento Animal
/
Modelos Animais de Doenças
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Trends Pharmacol Sci
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Brasil