Design and synthesis of fluorescent SGLT2 inhibitors.
Bioorg Med Chem Lett
; 18(18): 4944-7, 2008 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-18755586
ABSTRACT
The design and synthesis of the first fluorophore-conjugated SGLT2 inhibitors is described. The mode of linking the fluorophore to the SGLT2 pharmacophore was found to be crucial in achieving optimum potency. Superior potency to phlorizin was provided by examples containing TAMRA, BODIPY, Cy3B and NBD fluorophores.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Corantes Fluorescentes
/
Inibidores do Transportador 2 de Sódio-Glicose
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Reino Unido