A nonlinear mixed effects IVIVC model for multi-release drug delivery systems.
J Pharmacokinet Pharmacodyn
; 35(4): 423-41, 2008 Aug.
Article
em En
| MEDLINE
| ID: mdl-18780164
ABSTRACT
The purpose of this analysis was the development of an IVIVC model, which involves a convolution step as described by O'Hara et al. and to describe a dual-release system a controlled release formulation, which contains an initial immediate release element. Four formulations of Galantamine were used to test this modelling technique and a level A IVIVC, which meets the FDA criteria for internal and external validation, was successfully developed.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Dinâmica não Linear
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
America do norte
Idioma:
En
Revista:
J Pharmacokinet Pharmacodyn
Assunto da revista:
FARMACOLOGIA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Bélgica