Deep brain stimulation of the subthalamic nucleus and cognitive functions in Parkinson's disease.
Prague Med Rep
; 108(4): 315-23, 2007.
Article
em En
| MEDLINE
| ID: mdl-18780643
ABSTRACT
Deep brain stimulation of the subthalamic nucleus (DBS/STN) is an effective treatment for motor symptoms in advanced Parkinson's disease (PD). However, it is less clear how DBS/STN affects cognitive functions. We investigated 19 PD patients (13 male, 6 female, mean age 57 +/- 6, mean PD duration 15 +/- 4 years) who received bilateral DBS/STN. Neuropsychological assessment was done before the surgery and at least 12 months after DBS implantation. The patients were examined in their optimal motor status. Global cognitive performance measured by Mattis Dementia Rating Scale was not significantly changed after DBS STN. The performance in Wechsler Memory Scale III decreased in the subtest Logical Memory, in delayed recall (p < 0.05) and in recognition (p < 0.05). In Stroop Test, the performance worsened in the second (p < 0.05), and third condition (p < 0.01) measuring interference and ability to suppress automatic reactions. In conclusion, patients treated by DBS/STN tend to worsen in executive functions and in logical memory.
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Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Cognição
/
Núcleo Subtalâmico
/
Estimulação Encefálica Profunda
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Prague Med Rep
Assunto da revista:
MEDICINA
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
República Tcheca