Corticotropin-releasing hormone acts on CRH-R1 to inhibit the spontaneous contractility of non-labouring human myometrium at term.
Life Sci
; 83(17-18): 620-4, 2008 Oct 24.
Article
em En
| MEDLINE
| ID: mdl-18805429
ABSTRACT
AIMS:
Corticotropin-releasing hormone (CRH) has been implicated in the mechanisms controlling human parturition. The aims of the present study were to explore effects of CRH on contractility of human term myometrium and compare these effects in labouring and non-labouring myometrial strips. MAINMETHODS:
The cumulative effects of CRH (10(-10) to 10(-7) mol/l) on the spontaneous contractility of labouring and non-labouring myometrial samples were evaluated using isometric tension recordings. KEYFINDINGS:
CRH exhibited a concentration-dependent relaxant effect on spontaneous contractions in non-labouring term myometrium. This effect was mediated principally via a reduction in the amplitude rather than any changes in the frequency of contractions. The CRH-induced inhibitory effect on contractility could be blocked by pre-treatment with a CRH-R1 antagonist antalarmin, but not by pre-treatment with the CRH-R2 antagonist astressin 2B. CRH had no effect on spontaneous contractions in the labouring myometrium, as no change in either the amplitude or the frequency was observed.SIGNIFICANCE:
Our findings indicate that CRH acts on CRH-R1 to inhibit spontaneous contractions in term myometrium from women who were not undergoing labour, but not those who were undergoing labour, supporting the hypothesis that CRH exerts dual effect on myometrium during pregnancy.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Contração Uterina
/
Gravidez
/
Hormônio Liberador da Corticotropina
/
Receptores de Hormônio Liberador da Corticotropina
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Miométrio
Limite:
Female
/
Humans
Idioma:
En
Revista:
Life Sci
Ano de publicação:
2008
Tipo de documento:
Article