Imidazoles: SAR and development of a potent class of cyclin-dependent kinase inhibitors.
Bioorg Med Chem Lett
; 18(20): 5487-92, 2008 Oct 15.
Article
em En
| MEDLINE
| ID: mdl-18815031
ABSTRACT
An imidazole series of cyclin-dependent kinase (CDK) inhibitors has been developed. Protein inhibitor structure determination has provided an understanding of the emerging structure activity trends for the imidazole series. The introduction of a methyl sulfone at the aniline terminus led to a more orally bioavailable CDK inhibitor that was progressed into clinical development.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Quinases Ciclina-Dependentes
/
Imidazóis
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Reino Unido