Structural elucidation of a PDE-5 inhibitor detected as an adulterant in a health supplement.
J Pharm Biomed Anal
; 48(4): 1070-5, 2008 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-18829198
ABSTRACT
A PDE-5 inhibitor was detected and isolated from a health supplement claimed to be a preparation of fresh oyster extracts and be able to promote and support healthy sexual function and endurance, etc. The structure of this PDE-5 inhibitor was elucidated using LC-UV, LC-TOF-MS, MS-MS, IR spectroscopy, and 2D NMR. It was characterized as 8-(2-(4-(hydroxymethyl)piperidin-1-yl)benzylamino)-3-ethyl-1H-imidazo[4,5-g]quinazoline-2(3H)-thione, a compound reported to be a PDE-5 inhibitor.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Inibidores de Fosfodiesterase
/
Quinazolinas
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Contaminação de Medicamentos
/
Suplementos Nutricionais
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Imidazóis
/
Disfunção Erétil
Limite:
Humans
/
Male
Idioma:
En
Revista:
J Pharm Biomed Anal
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Singapura