Plasma markers of inflammation and incidence of hospitalisations for COPD: results from a population-based cohort study.
Thorax
; 64(3): 211-5, 2009 Mar.
Article
em En
| MEDLINE
| ID: mdl-18988660
ABSTRACT
BACKGROUND:
The relationship between plasma markers of inflammation and the incidence of chronic obstructive pulmonary disease (COPD) is still unclear. This population-based study explored whether raised levels of five inflammation-sensitive plasma proteins (ISPs) predicted hospital admissions for COPD during 25 years of follow-up.METHODS:
Spirometric tests and measurements of five ISPs (fibrinogen, ceruloplasmin, alpha(1)-antitrypsin, haptoglobin, orosomucoid) were performed in 5247 apparently healthy men from the city of Malmö (mean age 46 years). The incidence of hospitalisations for COPD was studied in relation to the number of ISPs in the fourth quartile.RESULTS:
During the follow-up period, 258 men were admitted to hospital with COPD, 211 of whom were smokers at baseline. The incidence of hospital admissions for COPD was significantly associated with the number of raised ISPs. Adjusted for risk factors, the hazards ratio (95% CI) was 1.00 (reference), 1.28 (0.9 to 1.9), 1.29 (0.8 to 2.0) and 2.30 (1.6 to 3.2), respectively, for men with 0, 1, 2 and >or=3 ISPs in the top quartile (p for trend <0.001). This relationship was consistent in men with high and low lung function at baseline. The relationship with the incidence of hospital admissions for COPD was largely the same for all individual ISPs.CONCLUSION:
Raised plasma ISP levels are associated with an increased incidence of COPD requiring hospitalisation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Fase Aguda
/
Doença Pulmonar Obstrutiva Crônica
/
Hospitalização
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Thorax
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Suécia