Graft-versus-host reaction. Cutaneous manifestations following bone marrow transplantation.
Arch Dermatol
; 113(8): 1087-91, 1977 Aug.
Article
em En
| MEDLINE
| ID: mdl-18997
ABSTRACT
The distinctive cutaneous changes that occur in both the acute and chronic forms of the graft-vs-host reaction (GVHR) are described in two living patients in whom the GVHR developed after bone marrow transplantation for aplastic anemia. In the skin, the mild form of the acute GVHR is recognized as a subtle macular erythema, and the severe form appears as erythematous papules and violaceous macules with scale. Skin biopsy specimens in both of the acute forms show vacuolar alterations of the epidermal basal-cell layer with a perivenular infiltrate of lymphocytes. The chronic GVHR evolves from generalized scaling to diffuse areas of aclerotic and atrophic skin with a curious reticulated hyperpigmentation, ulcerations, and alopecia. Histopathologic study shows collagenization of the dermis that can be correlated with the clinical sclerodermoid changes. Owing to its visibility, the skin offers a unique opportunity for the early recognition of the GVHR.
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Base de dados:
MEDLINE
Assunto principal:
Manifestações Cutâneas
/
Células da Medula Óssea
/
Transplante de Medula Óssea
/
Reação Enxerto-Hospedeiro
Tipo de estudo:
Etiology_studies
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Arch Dermatol
Ano de publicação:
1977
Tipo de documento:
Article