[Expression of bcl-2 and bax genes in the liver cancer cell line HepG2 after apoptosis induced by essential oils from Rosmarinus officinalis].
Zhong Yao Cai
; 31(6): 877-9, 2008 Jun.
Article
em Zh
| MEDLINE
| ID: mdl-18998574
ABSTRACT
OBJECTIVE:
To investigate the expression of bcl-2 and bax genes in the liver cancer cell line HepG2 after apoptosis induced by essential oils from Rosmarinus officinalis.METHODS:
Essential oils from Rosmarinus officinalis were collected by steam distillation, then its chemical composition was determined by GC-MS. Expression of bcl-2 and bax genes were detected by immunohistochemical method.RESULTS:
The liver cancer cell line HepG2 was treated with essential oils from Rosmarinus officinalis at various concentrations for different duration. Expression of bcl-2 gene reduced and expression of bax gene increased in a dose and time dependent manner.CONCLUSION:
Essential oils from Rosmarinus officinalis can affect the pattern of bcl-2 and bax genes expressions, and this may increase the apoptosis of liver cancer cell line HepG2.
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Base de dados:
MEDLINE
Assunto principal:
Óleos Voláteis
/
Apoptose
/
Proteínas Proto-Oncogênicas c-bcl-2
/
Rosmarinus
/
Proteína X Associada a bcl-2
Limite:
Humans
Idioma:
Zh
Revista:
Zhong Yao Cai
Assunto da revista:
TERAPIAS COMPLEMENTARES
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
China