Titanium dioxide induced cell damage: a proposed role of the carboxyl radical.
Mutat Res
; 660(1-2): 79-82, 2009 Jan 15.
Article
em En
| MEDLINE
| ID: mdl-19013474
ABSTRACT
Titanium dioxide (TiO(2)) nanoparticles have been shown to be genotoxic to cells exposed to ultraviolet A (UVA) radiation. Using the technique of electron spin resonance (ESR) spin trapping, we have confirmed that the primary damaging species produced on irradiation of TiO(2) nanoparticles is the hydroxyl (OH) radical. We have applied this technique to TiO(2)-treated fish and mammalian cells under in vitro conditions and observed the additional formation of carboxyl radical anions (CO(2)(-)) and superoxide radical anions (O(2)(-)). This novel finding suggests a hitherto unreported pathway for damage, involving primary generation of OH radicals in the cytoplasm, which react to give CO(2)(-) radicals. The latter may then react with cellular oxygen to form O(2)(-) and genotoxic hydrogen peroxide (H(2)O(2)).
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Titânio
/
Dióxido de Carbono
Limite:
Animals
Idioma:
En
Revista:
Mutat Res
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Reino Unido