Camphor sulfonamide derivatives as novel, potent and selective CXCR3 antagonists.
Bioorg Med Chem Lett
; 19(1): 114-8, 2009 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-19014886
ABSTRACT
A series of N-arylpiperazine camphor sulfonamides was discovered as novel CXCR3 antagonists. The synthesis, structure-activity relationships, and optimization of the initial hit that resulted in the identification of potent and selective CXCR3 antagonists are described.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sulfonamidas
/
Cânfora
/
Receptores CXCR3
Limite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos