Three-dimensional structure of recombinant human interferon-gamma.
Science
; 252(5006): 698-702, 1991 May 03.
Article
em En
| MEDLINE
| ID: mdl-1902591
ABSTRACT
The x-ray crystal structure of recombinant human interferon-gamma has been determined with the use of multiple-isomorphous-replacement techniques. Interferon-gamma, which is dimeric in solution, crystallizes with two dimers related by a noncrystallographic twofold axis in the asymmetric unit. The protein is primarily alpha helical, with six helices in each subunit that comprise approximately 62 percent of the structure; there is no beta sheet. The dimeric structure of human interferon-gamma is stabilized by the intertwining of helices across the subunit interface with multiple intersubunit interactions.
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Base de dados:
MEDLINE
Assunto principal:
Interferon gama
Limite:
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1991
Tipo de documento:
Article