Novel polymeric coatings with the potential to control in-stent restenosis--an in vitro study.
J Biomater Appl
; 24(5): 437-52, 2010 Jan.
Article
em En
| MEDLINE
| ID: mdl-19033327
ABSTRACT
Restenosis following percutaneous coronary intervention (PCI) is a considerable problem in long-term performance of cardiovascular stents, with a functional endothelial cell monolayer being important in its prevention. This study evaluates the influence of polymer coatings on human aortic endothelial cells (HAEC) and coronary artery smooth muscle cells (HCASMC) in vitro, in terms of morphology, cell number, and phenotype. It was demonstrated that the polymer coatings can be tailored to enhance adhesion and growth of HAECs whilst suppressing that of HCASMCs. It is concluded that one of the polymer coatings (BTL 01015) shows potential as a stent coating to enhance re-endothelialization.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polímeros
/
Materiais Revestidos Biocompatíveis
/
Reestenose Coronária
/
Stents Farmacológicos
Limite:
Humans
Idioma:
En
Revista:
J Biomater Appl
Assunto da revista:
ENGENHARIA BIOMEDICA
Ano de publicação:
2010
Tipo de documento:
Article