Glomerular filtration rate and blood pressure are unchanged by increased sodium intake in atorvastatin-treated healthy men.
Scand J Clin Lab Invest
; 69(3): 323-9, 2009.
Article
em En
| MEDLINE
| ID: mdl-19051099
ABSTRACT
OBJECTIVE:
Improved cardiovascular survival during statin treatment might be due to effects in addition to cholesterol lowering. We hypothesize that sodium intake affects renal function and vasoactive hormones in atorvastatin-treated healthy subjects.METHODS:
In a randomized, placebo-controlled, double-blind, crossover study we measured the effect of a moderate change in sodium intake on glomerular filtration rate (GFR), blood pressure (BP), renal tubular function, plasma concentrations of vasoactive hormones and urinary excretion of aquaporin-2 (u-AQP2) in 22 healthy subjects. The subjects were randomized to standardized fluid intake and diet corresponding to the need for calories in the 4 days before each of the 2 examination days. In one of the periods they were randomized to receive sodium chloride tablets (2 g) thrice daily for 4 days. Two doses of atorvastatin (80 mg) were given; one at 2200 h the evening before the study day, the other at 0830 h in the morning.RESULTS:
24-h urinary sodium excretion increased by 23%. GFR and BP were unchanged. Sodium clearance, fractional excretion of sodium and u-AQP2 increased, whereas free water clearance decreased during high sodium intake. PRC and aldosterone were suppressed during the high sodium diet.CONCLUSIONS:
A change in dietary sodium intake of approximately 100 mmol daily does not change GFR and BP in atorvastatin-treated healthy men. The lack of change in BP might reflect that the subjects studied were not sodium sensitive, or that atorvastatin treatment modified sodium sensitivity.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Pirróis
/
Sódio
/
Pressão Sanguínea
/
Taxa de Filtração Glomerular
/
Ácidos Heptanoicos
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Scand J Clin Lab Invest
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Dinamarca