Discovery of a novel series of quinoxalines as inhibitors of c-Met kinase.
Bioorg Med Chem Lett
; 19(2): 397-400, 2009 Jan 15.
Article
em En
| MEDLINE
| ID: mdl-19059779
ABSTRACT
A series of quinoxaline inhibitors of c-Met kinase is described. The postulated binding mode was confirmed by an X-ray crystal structure and optimisation of the series was performed on the basis of this structure. Future directions for development of the series are discussed together with the identification of a novel quinoline scaffold.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Quinoxalinas
/
Proteínas Proto-Oncogênicas c-met
/
Inibidores Enzimáticos
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Reino Unido