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Effect of neuropeptide Y Y2 receptor deletion on emotional stress-induced neuronal activation in mice.
Nguyen, Ngoc Khoi; Sartori, Simone B; Herzog, Herbert; Tasan, Ramon; Sperk, Günther; Singewald, Nicolas.
Afiliação
  • Nguyen NK; Department of Pharmacology and Toxicology, University of Innsbruck, Peter-Mayr-Strasse 1, Innsbruck, Austria.
Synapse ; 63(3): 236-46, 2009 Mar.
Article em En | MEDLINE | ID: mdl-19084906
In different behavioral paradigms including the elevated plus maze (EPM), it was observed previously that deletion of the neuropeptide Y Y2 receptor subtype results in potent suppression of anxiety-related and stress-related behaviors. To identify neurobiological correlates underlying this behavioral reactivtiy, expression of c-Fos, an established early marker of neuronal activation, was examined in Y2 receptor knockout (Y2(-/-)) vs. wildtype (WT) mice. Mice were placed on the open arm (OA) or closed arm (CA) of the EPM for 10 min and the effect on regional c-Fos expression in the brain was investigated. The number of c-Fos positive neurons was significantly increased in both WT and Y2(-/-) lines after OA and CA exposure in 51 of 54 regions quantified. These regions included various cortical, limbic, thalamic, hypothalamic, and hindbrain regions. Genotype influenced c-Fos responses to arm exposures in 6 of the 51 activated regions: the cingulate cortex, barrel field of the primary somatosensory cortex, nucleus accumbens, dorsal lateral septum, amygdala and lateral periaqueductal gray. These differences in neuronal activity responses to the novel environments were more pronounced after OA than after CA exposure. Mice lacking Y2 receptors exhibited reduced neuronal activation when compared to WT animals in response to the emotional stressors. Reduced neuronal excitability in the identified brain areas relevant to the processing of motivated, explorative as well as anxiety-related behaviors is suggested to contribute to the reduced anxiety-related behavior observed in Y2(-/-) mice.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estresse Psicológico / Encéfalo / Receptores de Neuropeptídeo Y / Emoções Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Synapse Assunto da revista: NEUROLOGIA Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Áustria

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estresse Psicológico / Encéfalo / Receptores de Neuropeptídeo Y / Emoções Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Synapse Assunto da revista: NEUROLOGIA Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Áustria