Adjuvant CCNU (lomustine) and prednisone chemotherapy for dogs with incompletely excised grade 2 mast cell tumors.
J Am Anim Hosp Assoc
; 45(1): 14-8, 2009.
Article
em En
| MEDLINE
| ID: mdl-19122059
ABSTRACT
The use of adjuvant 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU; lomustine) to treat incompletely excised canine mast cell tumors (MCTs) has not been evaluated. Medical records of 12 dogs with grade 2 MCT treated with incomplete surgical excision and adjuvant CCNU and prednisone chemotherapy were reviewed. Local recurrence rate, metastasis rate, and survival time were evaluated. None of the dogs developed local recurrence or regional/ distant metastases. Two dogs developed fatal liver failure. The 1- and 2-year progression-free rates of surviving dogs were 100% and 77%, respectively. Postoperative adjuvant CCNU appears to be a useful alternative to radiation therapy for incompletely excised canine cutaneous MCTs.
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Base de dados:
MEDLINE
Assunto principal:
Prednisona
/
Sarcoma de Mastócitos
/
Antineoplásicos Hormonais
/
Antineoplásicos Alquilantes
/
Doenças do Cão
/
Lomustina
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
J Am Anim Hosp Assoc
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos