TGF-beta indirectly favors the development of human Th17 cells by inhibiting Th1 cells.
Eur J Immunol
; 39(1): 207-15, 2009 Jan.
Article
em En
| MEDLINE
| ID: mdl-19130583
ABSTRACT
Human Th17 clones and circulating Th17 cells showed lower susceptibility to the anti-proliferative effect of TGF-beta than Th1 and Th2 clones or circulating Th1-oriented T cells, respectively. Accordingly, human Th17 cells exhibited lower expression of clusterin, and higher Bcl-2 expression and reduced apoptosis in the presence of TGF-beta, in comparison with Th1 cells. Umbilical cord blood naïve CD161(+)CD4(+) T cells, which contain the precursors of human Th17 cells, differentiated into IL-17A-producing cells only in response to IL-1beta plus IL-23, even in serum-free cultures. TGF-beta had no effect on constitutive RORgamma t expression by umbilical cord blood CD161(+) T cells but it increased the relative proportions of CD161(+) T cells differentiating into Th17 cells in response to IL-1beta plus IL-23, whereas under the same conditions it inhibited both T-bet expression and Th1 development. These data suggest that TGF-beta is not critical for the differentiation of human Th17 cells, but indirectly favors their expansion because Th17 cells are poorly susceptible to its suppressive effects.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Subpopulações de Linfócitos T
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Fator de Crescimento Transformador beta
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Linfócitos T Auxiliares-Indutores
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Células Th1
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Interleucina-17
Limite:
Humans
Idioma:
En
Revista:
Eur J Immunol
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Itália