Infection by CagA-positive Helicobacter pylori strains may contribute to alter the sperm quality of men with fertility disorders and increase the systemic levels of TNF-alpha.
Dig Dis Sci
; 55(1): 94-100, 2010 Jan.
Article
em En
| MEDLINE
| ID: mdl-19160044
ABSTRACT
This study was aimed to address the possibility that Helicobacter pylori infection may play a detrimental role in semen quality of men with idiopathic infertility. Infection by H. pylori and by strains expressing CagA was determined in 80 male infertile patients by Western blotting and ELISA. Semen analysis was performed by light microscopy and transmission electron microscopy quantitatively elaborated (fertility index, immaturity, necrosis, and apoptosis percentages). Systemic levels of IL-6 and TNF-alpha were evaluated. Infertile patients infected with H. pylori showed a low sperm quality respective to uninfected patients. Particularly, in CagA-positive patients we observed a significant reduction in sperm motility and in the fertility index, while apoptosis and necrosis were increased. In these patients, the means of systemic TNF-alpha levels were higher than those of uninfected patients. The negative influence of CagA-positive H. pylori infection on sperm quality may help to understand the role of chronic infections in reproductive disorders.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Motilidade dos Espermatozoides
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Espermatozoides
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Proteínas de Bactérias
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Helicobacter pylori
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Infecções por Helicobacter
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Fator de Necrose Tumoral alfa
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Infertilidade Masculina
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Antígenos de Bactérias
Limite:
Adult
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Humans
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Male
Idioma:
En
Revista:
Dig Dis Sci
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Itália