Possible role of receptor heteromers in multiple sclerosis.
J Neural Transm (Vienna)
; 116(8): 989-94, 2009 Aug.
Article
em En
| MEDLINE
| ID: mdl-19229585
ABSTRACT
Recent results suggest that cytokine and glutamate receptors can interact directly and form receptor heteromers. Due to such heteromers, cytokines can act not only as classical neuromediators but also directly enhance glutamate gated ion channel activity via allosteric mechanisms. Our opinion is that such heteromers may lead to enhanced glutamate neurotoxicity in pathogenic processes of multiple sclerosis. Thus, agents targeting evolutionary conserved leucine-rich motifs responsible for such dimerization of receptors may represent a useful strategy to inhibit excitotoxicity in multiple sclerosis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptores de Glutamato
/
Receptores de Citocinas
/
Modelos Neurológicos
/
Esclerose Múltipla
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Neural Transm (Vienna)
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Federação Russa