The monocyte/macrophage as a therapeutic target in atherosclerosis.
Curr Opin Pharmacol
; 9(2): 109-18, 2009 Apr.
Article
em En
| MEDLINE
| ID: mdl-19230773
ABSTRACT
It is now clear that the monocyte/macrophage has a crucial role in the development of atherosclerosis. This cell appears to be involved in all stages of atherosclerotic plaque development and is increasingly seen as a candidate for therapeutic intervention and as a potential biomarker of disease progression and response to therapy. The main mechanisms related to the activity of the monocyte/macrophage that have been targeted for therapy are those that facilitate recruitment, cholesterol metabolism, inflammatory activity and oxidative stress. There is also increasing evidence that there is heterogeneity within the monocyte/macrophage population, which may have important implications for plaque development and regression. A better insight into how specific phenotypes may influence plaque progression should facilitate the development of novel methods of imaging and more refined treatments.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Monócitos
/
Aterosclerose
/
Macrófagos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Pharmacol
Assunto da revista:
FARMACOLOGIA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Reino Unido