Modulation of paracetamol and nefopam antinociception by serotonin 5-HT(3) receptor antagonists in mice.
Pharmacology
; 83(4): 243-6, 2009.
Article
em En
| MEDLINE
| ID: mdl-19270466
ABSTRACT
BACKGROUND/AIMS:
Post-operative nausea and vomiting are common adverse events that require administration of anti-emetic compounds, such as the serotonin 5-HT(3) receptor antagonists, but these drugs can also reduce the analgesic efficacy of some analgesics (paracetamol, tramadol).METHODS:
The present study was designed to explore the effect of 3 serotonin 5-HT(3) receptor antagonists on the antinociceptive efficacy of another frequently used post-operative analgesic, nefopam, in the mouse writhing and formalin tests.RESULTS:
Pre-treatment with tropisetron, ondansetron or MDL72222 did not significantly modify nefopam antinociception in both tests. However, paracetamol antinociception was blocked by ondansetron in the formalin test.CONCLUSION:
These results provide a rationale for the clinical use of nefopam with anti-emetics during surgery.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antagonistas da Serotonina
/
Antagonistas do Receptor 5-HT3 de Serotonina
/
Analgésicos
/
Nefopam
Limite:
Animals
Idioma:
En
Revista:
Pharmacology
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
França