Interfering with Wnt signalling alters the periodicity of the segmentation clock.
Dev Biol
; 330(1): 21-31, 2009 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-19272372
ABSTRACT
Somites are embryonic precursors of the ribs, vertebrae and certain dermis tissue. Somite formation is a periodic process regulated by a molecular clock which drives cyclic expression of a number of clock genes in the presomitic mesoderm. To date the mechanism regulating the period of clock gene oscillations is unknown. Here we show that chick homologues of the Wnt pathway genes that oscillate in mouse do not cycle across the chick presomitic mesoderm. Strikingly we find that modifying Wnt signalling changes the period of Notch driven oscillations in both mouse and chick but these oscillations continue. We propose that the Wnt pathway is a conserved mechanism that is involved in regulating the period of cyclic gene oscillations in the presomitic mesoderm.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Relógios Biológicos
/
Padronização Corporal
/
Proteínas Wnt
Limite:
Animals
Idioma:
En
Revista:
Dev Biol
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Reino Unido