Large-scale association study for structural soundness and leg locomotion traits in the pig.
Genet Sel Evol
; 41: 14, 2009 Jan 21.
Article
em En
| MEDLINE
| ID: mdl-19284518
ABSTRACT
BACKGROUND:
Identification and culling of replacement gilts with poor skeletal conformation and feet and leg (FL) unsoundness is an approach used to reduce sow culling and mortality rates in breeding stock. Few candidate genes related to soundness traits have been identified in the pig.METHODS:
In this study, 2066 commercial females were scored for 17 traits describing body conformation and FL structure, and were used for association analyses. Genotyping of 121 SNPs derived from 95 genes was implemented using Sequenom's MassARRAY system.RESULTS:
Based on the association results from single trait and principal components using mixed linear model analyses and false discovery rate testing, it was observed that APOE, BMP8, CALCR, COL1A2, COL9A1, DKFZ, FBN1 and VDBP were very highly significantly (P < 0.001) associated with body conformation traits. The genes ALOX5, BMP8, CALCR, OPG, OXTR and WNT16 were very highly significantly (P < 0.001) associated with FL structures, and APOE, CALCR, COL1A2, GNRHR, IHH, MTHFR and WNT16 were highly significantly (P < 0.01) associated with overall leg action. Strong linkage disequilibrium between CALCR and COL1A2 on SSC9 was detected, and haplotype -ACGACC- was highly significantly (P < 0.01) associated with overall leg action and several important FL soundness traits.CONCLUSION:
The present findings provide a comprehensive list of candidate genes for further use in fine mapping and biological functional analyses.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Suínos
/
Característica Quantitativa Herdável
/
Estudo de Associação Genômica Ampla
/
Membro Posterior
/
Locomoção
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Genet Sel Evol
Assunto da revista:
BIOLOGIA
/
GENETICA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos