Increased CXCL-13 levels in human African trypanosomiasis meningo-encephalitis.
Trop Med Int Health
; 14(5): 529-34, 2009 May.
Article
em En
| MEDLINE
| ID: mdl-19298637
ABSTRACT
OBJECTIVES:
To determine the role of the B-cell attracting chemokine CXCL-13, which may initiate B-cell trafficking and IgM production in diagnosing HAT meningo-encephalitis.METHODS:
We determined CXCL-13 levels by ELISA on paired sera and CSF of 26 patients from Angola and of 16 controls (six endemic and ten non-endemic). Results were compared to standard stage determination markers and IgM intrathecal synthesis.RESULTS:
CXCL-13 levels in patients' sera had a median value of 386.6 pg/ml and increased levels were associated with presence of trypanosomes in the CSF but not with other stage markers. CXCL-13 levels in patients' CSF had a median value of 80.9 pg/ml and increased levels were associated with all standard stage determination markers and IgM intrathecal synthesis.CONCLUSION:
CXCL-13 levels in CSF increased significantly during the course of HAT. Hence the value of CXCL-13 for diagnosis, follow-up or as a marker of disease severity should be tested in a well-defined cohort study.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tripanossomíase Africana
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Infecções Protozoárias do Sistema Nervoso Central
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Encefalite
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Quimiocina CXCL13
/
Meningite
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Africa
Idioma:
En
Revista:
Trop Med Int Health
Assunto da revista:
MEDICINA TROPICAL
/
SAUDE PUBLICA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
França