Sexual differentiation of the zebra finch song system: potential roles for sex chromosome genes.
BMC Neurosci
; 10: 24, 2009 Mar 23.
Article
em En
| MEDLINE
| ID: mdl-19309515
ABSTRACT
BACKGROUND:
Recent evidence suggests that some sex differences in brain and behavior might result from direct genetic effects, and not solely the result of the organizational effects of steroid hormones. The present study examined the potential role for sex-biased gene expression during development of sexually dimorphic singing behavior and associated song nuclei in juvenile zebra finches.RESULTS:
A microarray screen revealed more than 2400 putative genes (with a false discovery rate less than 0.05) exhibiting sex differences in the telencephalon of developing zebra finches. Increased expression in males was confirmed in 12 of 20 by qPCR using cDNA from the whole telencephalon; all of these appeared to be located on the Z sex chromosome. Six of the genes also showed increased expression in one or more of the song control nuclei of males at post-hatching day 25. Although the function of half of the genes is presently unknown, we have identified three as 17-beta-hydroxysteroid dehydrogenase type IV, methylcrotonyl-CoA carboxylase, and sorting nexin 2.CONCLUSION:
The data suggest potential influences of these genes in song learning and/or masculinization of song system morphology, both of which are occurring at this developmental stage.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cromossomos Sexuais
/
Diferenciação Sexual
/
Telencéfalo
/
Vocalização Animal
/
Expressão Gênica
/
Tentilhões
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
BMC Neurosci
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos