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Single-nucleotide polymorphisms in the promoter of the CDK5 gene and lung cancer risk in a Korean population.
Choi, Hyo Seon; Lee, Youngin; Park, Kyong Hwa; Sung, Jae Sook; Lee, Jong-Eun; Shin, Eun-Soon; Ryu, Jeong-Seon; Kim, Yeul Hong.
Afiliação
  • Choi HS; Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University Anam Hospital, Seoul, Korea.
J Hum Genet ; 54(5): 298-303, 2009 May.
Article em En | MEDLINE | ID: mdl-19343042
Cyclin-dependent kinase 5 (CDK5), a proline-directed serine/threonine kinase, which was originally known for its regulatory role in neuronal activities, has recently been suggested to play a role in extraneuronal activities. For example, a recent study detected overexpression of the CDK5 gene in non-small-cell lung cancer. Therefore, in order to explore the association of the CDK5 gene with lung cancer risk in a Korean population, the genotypes of the CDK5 promoter region were determined in 407 lung cancer patients and 402 normal participants. The result showed that the -904 G>A genotype affected susceptibility to lung cancer risk (odd ratios (OR)=1.53, 95% confidence interval (CI)=1.02-2.32). Furthermore, subsequent haplotype analysis of three single-nucleotide polymorphism (SNP) regions suggested that the A-G-C haplotype was associated with a higher overall risk of lung cancer (OR=1.59, 95% CI=1.16-2.18). These results suggest that CDK5 promoter polymorphisms contribute to the genetic susceptibility to lung cancer in the Korean population.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regiões Promotoras Genéticas / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único / Povo Asiático / Quinase 5 Dependente de Ciclina / Neoplasias Pulmonares Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Revista: J Hum Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2009 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regiões Promotoras Genéticas / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único / Povo Asiático / Quinase 5 Dependente de Ciclina / Neoplasias Pulmonares Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Revista: J Hum Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2009 Tipo de documento: Article