Intraperitoneal EMLA (lidocaine/prilocaine) to prevent abdominal adhesion formation in a rat peritonitis model.
Bratisl Lek Listy
; 109(12): 537-43, 2008.
Article
em En
| MEDLINE
| ID: mdl-19348374
ABSTRACT
OBJECTIVE:
The accelerative effect of EMLA (eutectic mixture of lidocaine 2.5% and prilocaine 2.5%) in the wound healing process is known. We hypothesised that post-operative peritoneal adhesions may be reduced with intra-peritoneal EMLA administration in a model of bacterial peritonitis. STUDYDESIGN:
Bacterial peritonitis was induced in 24 rats by cecal ligation and puncture. The rats were randomly assigned to one of four groups. Group 1 (n=6)) received EMLA intraperitoneally, group 2 (n=6) received 2% lidocaine hcl solution intraperitoneally, the third group received one dose (100 mg/kg) of ceftriaxone sodium (Rocephin, Roche, 1 g) intraperitoneally one day after cecal ligation and puncture procedure, and in control group (group 4, n=6), no fluid or medicine was introduced into the abdomens of the rats. All animals were killed 14 days later in order to assess the adhesion score. Tissue antioxidant levels were measured in 1 g tissue samples taken from the abdominal wall.RESULTS:
The adhesion score was significantly lower in the EMLA group than in the lidocaine and control groups. The catalase levels were higher in the lidocaine and control groups than in EMLA group.CONCLUSIONS:
Intraperitoneal EMLA inhibited the formation of postoperative intra-abdominal adhesions without compromising the wound healing in this bacterial peritonitis rat model. EMLA also decreased the oxidative stress during peritonitis (Tab. 1, Fig. 7, Ref. 27). Full Text (Free, PDF) www.bmj.sk.
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Base de dados:
MEDLINE
Assunto principal:
Doenças Peritoneais
/
Peritonite
/
Prilocaína
/
Anestésicos Combinados
/
Anestésicos Locais
/
Lidocaína
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Bratisl Lek Listy
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Turquia