Clinical and molecular features of mucosa-associated lymphoid tissue (MALT) lymphomas of salivary glands.
Head Neck
; 31(9): 1181-7, 2009 Sep.
Article
em En
| MEDLINE
| ID: mdl-19360750
ABSTRACT
BACKGROUND:
To analyze clinical features and to discuss the modality of investigation and treatment of a series of mucosa-associated lymphoid tissue (MALT) lymphomas. To investigate the prevalence of aberrant promoter methylation, responsible for gene inactivation, in a selected panel of genes potentially involved in the pathogenesis of B-cell malignancies as O6-methylguanine-DNA methyltransferase (MGMT), p73, death-associated protein kinase (DAP-k).METHODS:
Nine patients with primary MALT lymphoma of the salivary glands were retrospectively reviewed. MGMT, p73, DAP-k apoptotic pathways were tested.RESULTS:
Methylation of DAP-k was common (5/8; 63%). Histological examination ensured diagnostic confirmation, whereas fine-needle aspiration cytology was not definitively diagnostic.CONCLUSION:
Histological assessment is the gold standard in the diagnosis of salivary gland lesions. Parotidectomy represents a safe and reliable diagnostic tool leading to a definite diagnosis of MALT lymphomas in all cases and curative without other treatment in early-stage MALT lymphoma.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias das Glândulas Salivares
/
Proteínas Nucleares
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Metilases de Modificação do DNA
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Proteínas Quinases Dependentes de Cálcio-Calmodulina
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Linfoma de Zona Marginal Tipo Células B
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Proteínas Supressoras de Tumor
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Enzimas Reparadoras do DNA
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Proteínas de Ligação a DNA
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Proteínas Reguladoras de Apoptose
Tipo de estudo:
Risk_factors_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Head Neck
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Itália