Synthesis and evaluation of piperazine and homopiperazine analogues of JS-K, an anti-cancer lead compound.
Bioorg Med Chem Lett
; 19(10): 2760-2, 2009 May 15.
Article
em En
| MEDLINE
| ID: mdl-19364650
ABSTRACT
Here we report a number of novel JS-K structural analogues with sub-micromolar anti-proliferative activities against human leukemia cell lines HL-60 and U937; JS-K is the anti-cancer lead compound O(2)-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate. The ability of these compounds to generate intracellular nitric oxide correlated well with their observed anti-proliferative effects analogues that had potent inhibitory activity against leukemia cells formed elevated levels of intracellular nitric oxide.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Piperazinas
/
Compostos Azo
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos