[Selective effect of nispex in inhibiting human cancer cell proliferation and inducing cell apoptosis].
Zhongguo Zhong Xi Yi Jie He Za Zhi
; 29(2): 148-52, 2009 Feb.
Article
em Zh
| MEDLINE
| ID: mdl-19382477
ABSTRACT
OBJECTIVE:
To observe the in vitro anticancer effect of Nispex, the total flavonoids extract from Scurrula parasitic L.METHODS:
The cell proliferation inhibitory effects of Nispex on various kinds of tumor cells or non-tumor cells in human and rats were detected with MTT assay and colony forming assay respectively, the cell apoptosis induced by Nispex was detected by AO/EB fluorescence staining, TUNEL assay and AnnexinV-FITC/PI flow cytometry.RESULTS:
Nispex could significantly inhibit human cancer cell proliferation and induce human cancer cell apoptosis, especially to the proliferative cell group, but its inhibition on human non-tumor cell was insignificant, and showed no effect on murine cancer cells in the tested scope.CONCLUSION:
Nispex is a nature plant extract which shows good selectivity for killing human cancer cell.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Flavonoides
/
Apoptose
/
Loranthaceae
/
Neoplasias
/
Antineoplásicos Fitogênicos
Limite:
Animals
/
Humans
Idioma:
Zh
Revista:
Zhongguo Zhong Xi Yi Jie He Za Zhi
Assunto da revista:
TERAPIAS COMPLEMENTARES
Ano de publicação:
2009
Tipo de documento:
Article