Early pregnancy loss in celiac women: The role of genetic markers of thrombophilia.
Dig Liver Dis
; 41(10): 717-20, 2009 Oct.
Article
em En
| MEDLINE
| ID: mdl-19395327
ABSTRACT
BACKGROUND:
Adverse pregnancy outcomes are more frequent in celiac than in non-celiac women.AIMS:
To investigate a possible role of genetic prothrombotic variants in early pregnancy loss of celiac women.METHODS:
Thirty-nine celiac women who had experienced early pregnancy losses (at least two losses within the first 3 months of pregnancy), and 72 celiac women with a history of one or more normal pregnancies and no pregnancy loss (controls) entered the study, at the moment of diagnosis for celiac disease. A clinical history was obtained from each woman. DNA from leukocytes was tested for factor V Leiden (mutation G1691A), factor V R2 (H1299R), factor II (G20210A), methylenetetrahydrofolate reductase (MTHFR) (C677T and A1298C), beta-fibrinogen (-455 G>A), PAI-1 alleles 4G/5G, factor XIII (V34L), and HPA-1 (L33P).RESULTS:
Age at diagnosis was significantly higher (p=0.002) in the celiac women with pregnancy losses than in controls. Of the gene variants studied, the allelic frequency of 4G variant of PAI-1, and the frequency of mutant genotypes were significantly more frequent in the group of celiac women with early pregnancy loss (p=0.00003 and 0.028, respectively). Surprisingly, the beta-fibrinogen -455 G>A genotype distribution (but not the allelic frequency of the variant allele) significantly differed between the two groups, since variant genotypes were more frequent in the control group (p=0.009).CONCLUSION:
The 4G variant of the PAI-I gene may predispose to miscarriage a subset of celiac women; these data should be verified on larger populations.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Complicações Hematológicas na Gravidez
/
Doença Celíaca
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Aborto Espontâneo
/
Trombofilia
Tipo de estudo:
Observational_studies
Limite:
Adult
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Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Dig Liver Dis
Assunto da revista:
GASTROENTEROLOGIA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Itália