Use of phosphatide precursors to promote synaptogenesis.
Annu Rev Nutr
; 29: 59-87, 2009.
Article
em En
| MEDLINE
| ID: mdl-19400698
ABSTRACT
New brain synapses form when a postsynaptic structure, the dendritic spine, interacts with a presynaptic terminal. Brain synapses and dendritic spines, membrane-rich structures, are depleted in Alzheimer's disease, as are some circulating compounds needed for synthesizing phosphatides, the major constituents of synaptic membranes. Animals given three of these compounds, all nutrients-uridine, the omega-3 polyunsaturated fatty acid docosahexaenoic acid, and choline-develop increased levels of brain phosphatides and of proteins that are concentrated within synaptic membranes (e.g., PSD-95, synapsin-1), improved cognition, and enhanced neurotransmitter release. The nutrients work by increasing the substrate-saturation of low-affinity enzymes that synthesize the phosphatides. Moreover, uridine and its nucleotide metabolites activate brain P2Y receptors, which control neuronal differentiation and synaptic protein synthesis. A preparation containing these compounds is being tested for treating Alzheimer's disease.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fosfolipídeos
/
Sinapses
/
Pró-Fármacos
/
Doença de Alzheimer
Limite:
Humans
Idioma:
En
Revista:
Annu Rev Nutr
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos