Efficacy of ossein-hydroxyapatite complex compared with calcium carbonate to prevent bone loss: a meta-analysis.
Menopause
; 16(5): 984-91, 2009.
Article
em En
| MEDLINE
| ID: mdl-19407667
ABSTRACT
OBJECTIVE:
There is increasing evidence to suggest that ossein-hydroxyapatite complex (OHC) is more effective than calcium supplements in maintaining bone mass. The aim of this meta-analysis was to determine whether OHC has a different clinical effect on bone mineral density (BMD) compared with calcium carbonate (CC).METHODS:
A meta-analysis of randomized controlled clinical trials was carried out to evaluate the efficacy of OHC versus CC on trabecular BMD. We identified publications on clinical trials by a search of electronic databases, including MEDLINE (1966-November 2008), EMBASE (1974-November 2008), and the Cochrane Controlled Clinical Trials Register.The primary endpoint was percent change in BMD from baseline. Data were pooled in a random-effects model, and the weighted mean difference was calculated. A sensitivity analysis that excluded trials without full data was performed.RESULTS:
Of the 18 controlled trials initially identified, 6 were included in the meta-analysis. There was no significant heterogeneity among the included trials. The percent change in BMD significantly favored the OHC group (1.02% [95% CI, 0.63-1.41], P < 0.00001). These results were confirmed in the sensitivity analysis.CONCLUSIONS:
OHC is significantly more effective in preventing bone loss than CC.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Osteoporose
/
Doenças Ósseas Metabólicas
/
Reabsorção Óssea
/
Carbonato de Cálcio
/
Densidade Óssea
/
Durapatita
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Menopause
Assunto da revista:
GINECOLOGIA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Espanha