No association between Cholinergic Muscarinic Receptor 2 (CHRM2) genetic variation and cognitive abilities in three independent samples.
Behav Genet
; 39(5): 513-23, 2009 Sep.
Article
em En
| MEDLINE
| ID: mdl-19418213
ABSTRACT
Cognitive ability has a substantial genetic component and more than 15 candidate genes have been identified over the past 8 years. One gene that has been associated with general cognitive ability is the cholinergic muscarinic 2 receptor (CHRM2). In an attempt to replicate this finding we typed marker rs8191992 (the originally reported CHRM2 SNP) in two population based cohorts-one Scottish aged over 50 years (N = 2,091) and the other English comprising non-demented elderly participants (N = 758)-and a family-based Australian adolescent sample (N = 1,537). An additional 29 SNPs in CHRM2 were typed in the Australian sample and a further seven in the English cohort. No significant association was found between CHRM2 and diverse measures of cognitive ability in any of the samples. In conclusion, this study does not support a role for CHRM2 in cognitive ability.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Variação Genética
/
Cognição
/
Receptor Muscarínico M2
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
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Female
/
Humans
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Male
/
Middle aged
País/Região como assunto:
Europa
/
Oceania
Idioma:
En
Revista:
Behav Genet
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Austrália