Preparation, antibacterial properties and biocompatibility studies on vancomycin-poly(D,L)-lactic loaded plates.
Int Orthop
; 34(5): 755-9, 2010 Jun.
Article
em En
| MEDLINE
| ID: mdl-19466408
ABSTRACT
In the clinic, implant-associated infections are the chief risk facing orthopaedics and traumatology departments. Vancomycin-poly(D,L)-lactic acid (PDLLA) loaded plates were prepared by using solvent casting technology. The bacteriostatic activity to Staphylococcus aureus was evaluated in vitro. The biocompatibility of the plates was investigated by acute systemic toxicity test, haemolytic test, cytotoxicity test, etc. The in vitro inhibition test of Staphylococcus aureus showed that the plates had an inhibitory effect on Staphylococcus aureus. There was no toxicity for the vancomycin-PDLLA loaded plates. There was a good biocompatibility for the vancomycin-PDLLA loaded plates. These findings indicate that the plate maybe used to prevent or cure infection.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Staphylococcus aureus
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Vancomicina
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Materiais Revestidos Biocompatíveis
/
Antibacterianos
Limite:
Animals
Idioma:
En
Revista:
Int Orthop
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
China